Formation of identical metabolites from piperazine- and dimethylamino-substituted phenothiazine drugs in man, rat and dog

Identification of amperozide metabolites

Identification of amperozide metabolites in urine from rats, rabbits, dogs and man by Frit-FAB LC/MS using deuterated solvents to gain additional structural information

✍ P. O. Edlund 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 937 KB

## Abstract A general procedure for screening of amperozide, __N__‐ethyl‐4‐[4,4‐bis(__p__‐fluorophenylbutyl)]‐1‐piperazine carboxamide, labelled with ^3^H and ^14^C was developed. Urine extracts were first fractionated by preparative reversedphase chromatography with an acetonitrile gradient elutio