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Formation of G-quadruplex-hemin DNAzyme based on human telomere elongation and its application in telomerase activity detection

✍ Scribed by Ying Li; Xia Li; Xiaoting Ji; Xuemei Li

Book ID: 108072436
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 332 KB
Volume: 26
Category: Article
ISSN: 0956-5663
DOI: 10.1016/j.bios.2011.03.041

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Here we report that human telomere guanine-rich sequence AGGG(TTAGGG) 3 (G4) and hemin can form a G-quadruplex-hemin complex (GHC) which exhibits good electrochemical characteristics. The redox signals of the complex and the electrocatalytic activities toward the reduction of hydrogen peroxide have