Development of pegylated liposomal vincr
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Jingxia Cui; Chunlei Li; Caixia Wang; Yanhui Li; Lan Zhang; Li Zhang; Xian Xiu;
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Article
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2011
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John Wiley and Sons
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English
⚖ 396 KB
The purpose of this study is to develop novel stable PEGylated liposome vincristine formulations with optimal antitumor efficacy. Vincristine could interact with negatively charged distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG), leading to rapid drug release from vesicles. To impr