Formation of DNA adducts in tissues of mouse progeny through transplacental contamination and/or lactation after administration of a single dose of ochratoxin A to the pregnant mother
✍ Scribed by T. Petkova-Bocharova; I.I. Stoichev; I.N. Chernozemsky; M. Castegnaro; A. Pfohl-Leszkowicz
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 172 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0893-6692
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✦ Synopsis
Ochratoxin A (OTA) is a mycotoxin which has been from control animals. Different adducts were most detected in foods of plant origin, in edible animal important in kidney and liver DNA and some were tissues, and in human sera, urine, and milk in many organ-specific. High levels of DNA adducts were countries. OTA is nephrotoxic and carcinogenic in detected in the kidneys of male progeny, whereas mice and rats and is suspected to play a key role in the female progeny and the mothers they were in the etiology of Balkan endemic nephropathy detected almost exclusively in the liver. This result and/or associated urinary tract tumors. In the pres-correlates well with the carcinogenicity in mice: the ent study, some early signs of genetic impairment, target organ for males is the kidney, while for feincluding the presence of DNA adducts in target males it is the liver. High levels of DNA adducts tissues from the progeny of mice after administration were also found in fetuses. These results provide of a single OTA dose during late pregnancy, have evidence for a direct genotoxic action of OTA in been investigated. By the 32 P-postlabeling method, the progeny through transplacental contamination, several characteristic DNA adducts with the same which constitutes a new serious health hazard of R f values were detected in kidney and liver of both exposure to this toxin.