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Formation of Cyclobutylidenepyrazolines by Methanolysis of 6-(2,3,3-Trifluorocyclobutenyl)-4,5-diazaspiro[2.4]hept-4-ene

✍ Scribed by Ekaterina V. Guseva; Nikolay V. Volchkov; Yury V. Tomilov; Boris B. Averkiev; Oleg M. Nefedov


Book ID
102172687
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
92 KB
Volume
2003
Category
Article
ISSN
1434-193X

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✍ Behrendt, Uwe ;Gabor, Barbara ;Mynott, Richard ;Butenschön, Holger 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 996 KB

## Abstract The chemistry of the highly substituted cyclobutanone derivative 2, which is easily accessible from 1, is dominated by the steric hindrance caused by the substitutents: Reduction with hydride reagents and nucleophilic additions with methyllithium are less stereoselective than correspond