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Formation of circular amplifications in Saccharomyces cerevisiae by a breakage-fusion-bridge mechanism

โœ Scribed by Irene K. Moore; Michael P. Martin; Michael J. Dorsey; Charlotte E. Paquin


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
125 KB
Volume
36
Category
Article
ISSN
0893-6692

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Gene amplification is a common feature of tumors. Overexpression of some amplified genes plays a role in tumor progression. Gene amplification can occur either extrachromosomally as double-minute chromosomes (dmin) or intrachromosomally in the form of homogeneously staining regions (hsrs). Approxima