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Formation of cholic acid and chenodeoxycholic acid from 7α-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes

✍ Scribed by Gerd Sauter; Sven Fischer; Sascha Pahernik; Hans-Günter Koebe; Gustav Paumgartner

Book ID
115741654
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
412 KB
Volume
1300
Category
Article
ISSN
0005-2760

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Formation of 7α- and 7β-hydroxylated bil
Formation of 7α- and 7β-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria
✍ Junichi Shoda; Anders Toll; Magnus Axelson; Fritz Pieper; Kjell Wikvall; Dr. Jan 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 951 KB

In a search for enzymes involved in the formation of bile acids from 27-hydroxycholesterol in humans, the metabolism of this and other side-chain oxygenated steroids was studied in human liver microsomes and mitochondria. The microsomal fraction contained enzyme(s) catalyzing 7a-hydroxylation of 27-