✦ LIBER ✦

Formation of cartilage tissue in vitro

✍ Scribed by Michael Solursh

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 280 KB
Volume: 45
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240450306

No coin nor oath required. For personal study only.

✦ Synopsis

Articular cartilage is notoriously defective in its capacity for self-repair, making joints particularly sensitive to degenerative processes. However, methods are now available for the preparation of large numbers of differentiated chondrocytes from a small biopsy sample from any patient. The cells are amplified by proliferation as fibroblast-like cells that will re-express the cartilage phenotype when placed in suspension or gel culture. The chondrocytes can be collected from gel cultures after agarase treatment and reconstituted into cartilage tissue in pellet cultures. In addition, these chondrocytes can be suspended in an appropriate delivery vehicle and implanted into defect sites with a high reparative success rate in an animal model. Appropriate procedures can now be tested in appropriate patient populations.

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