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Formation of a protection film on the human skin by microparticles

โœ Scribed by J. Lademann; S. Schanzer; H. Richter; C. Antoniou; F. Knorr; W. Sterry; A. Patzelt

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
600 KB
Volume
5
Category
Article
ISSN
1612-2011

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โœฆ Synopsis

Laser scanning microscopy and tape stripping, in combination with optical methods, were used to analyze the distribution and penetration of a barrier cream into the horny layer (stratum corneum) of the human skin under in vivo conditions. The barrier cream contained microparticles of 10 -100 ยตm loaded with antioxidant substances. The cream was designed for protection of the skin surface against the destructive action of free radicals, produced by systemically applied chemotherapeutic agents reaching the skin surface via the sweat. Both methods were able to demonstrate that the barrier cream was distributed homogeneously on the skin surface forming a protection film. A penetration into deeper parts of the stratum corneum (SC) was not observed. Wavelength, nm tape 1 extracted with ethanol tape 2 extracted with ethanol tape 1 tape 2 Absorbance 0.6 0.5 0.4 0.3 0.2 0.

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