Formation of a Complex of the Catalytic Subunit of Pyruvate Dehydrogenase Phosphatase Isoform 1 (PDP1c) and the L2 Domain Forms a Ca 2+ Binding Site and Captures PDP1c as a Monomer †

Probing a putative active site of the ca

Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesis

✍ Tatiana Karpova; Svitlana Danchuk; Boli Huang; Kirill M. Popov 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 208 KB

The catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) is a magnesium-dependent protein phosphatase that regulates the activity of mammalian pyruvate dehydrogenase complex. Based on the sequence analysis, it was hypothesized that PDP1c is related to the mammalian magnesium-dependent p