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Formal total synthesis of (±)-hirsutic acid C using the tandem Rh(I)-catalyzed [(5+2)+1] cycloaddition/aldol reaction

✍ Scribed by Changxia Yuan; Lei Jiao; Zhi-Xiang Yu


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
408 KB
Volume
51
Category
Article
ISSN
0040-4039

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An expeditious and high-yield formal syn
✍ Xiaohui Fan; Min-Xian Tang; Lian-Gang Zhuo; Yong Qiang Tu; Zhi-Xiang Yu 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 270 KB

An expeditious and high-yield formal synthesis of hirsutene has been achieved. This synthesis features Rh(I)-catalyzed [(5+2)+1] cycloaddition to construct a bicyclic cyclooctenone, which can be efficiently transformed to bicyclic diketone, an advanced intermediate for racemic and asymmetric synthes