Formal total synthesis of (±)-herbertenediol and (±)-mastigophorenes A and B
✍ Scribed by A Srikrishna; M.Srinivasa Rao
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 64 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The first synthesis of mastigophorenes A and B by oxidative phenolic coupling of partially protected derivatives of their joint natural monomeric half, herbertenediol, is described. The synthesis starts from this diol itself or from the corresponding aldehyde, both available by isolation from the li
Total Syntheses of (-)-Herbertenediol (I), (-)-Mastigophorene A (II), and (-)-Mastigophorene B (III). Combined Utility of Chiral Bicyclic Lactams and Chiral Aryl Oxazolines.
## Abstract Total enantioselective synthesis of the natural (‐)‐Herbertenediol (1) was accomplished in eleven steps with an overall yield of 15% starting from the 2‐methoxy‐4‐methyl‐phenol. The total synthesis features asymmetric intramolecular Heck reaction and Wolff‐Kishner‐Huang reduction. (a__R