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Formal Synthesis of (−)-Cyclaradine Using Ring Closing Metathesis

✍ Scribed by Raju, Gurrapu; Rao, Jalagam Prasada; Rao, Batchu Venkateswara


Book ID
124097280
Publisher
John Wiley and Sons
Year
2014
Tongue
German
Weight
178 KB
Volume
97
Category
Article
ISSN
0018-019X

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✍ Mukund K Gurjar; Dandepally Srinivasa Reddy 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 172 KB

A synthesis of stemoamide has been achieved from D-glucose. The stereocontrolled allylation under Barbier reaction conditions led to the installation of the 2-pyrrolidinone ring at C-3 followed by a ring-closing metathesis approach to construct the azepine ring system.