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Forced opiate withdrawal under anaesthesia augments and prolongs the occurrence of withdrawal signs in rats

✍ Scribed by Rainer Spanagel; Christian Kirschke; Felix Tretter; Florian Holsboer


Book ID
117512593
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
130 KB
Volume
52
Category
Article
ISSN
0376-8716

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## Abstract We previously described a decrease in withdrawal behaviors in opiate‐dependent rats that were chronically treated with very low doses of naltrexone in their drinking water. Attenuated expression of withdrawal behaviors correlated with decreased c‐Fos expression and intracellular signal