Force spectroscopy with single bio-molecules

✍ Scribed by Hauke Clausen-Schaumann; Markus Seitz; Rupert Krautbauer; Hermann E Gaub

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 382 KB
• Volume: 4
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(00)00126-5

✦ Synopsis

For many biological molecules, force is an important functional and structural parameter. With the rapidly growing knowledge about the relation between structure, function, and force, single-molecule force spectroscopy has become a versatile analytical tool for the structural and functional investigation of single bio-molecules in their native environments. Within the past year, detailed insights into binding potentials of receptor ligand pairs, protein folding pathways, molecular motors, DNA mechanics and the functioning of DNA-binding agents (such as proteins and drugs), as well as the function of molecular motors, have been obtained.