Folic acid treatment in methotrexate-treated rheumatoid arthritis patients: comment on the article by Furst and Kremer
✍ Scribed by Sarah L. Morgan; Anthony Saway; Graciela S. Alarcón
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 257 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0004-3591
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📜 SIMILAR VOLUMES
## Abstract ## Objective To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5‐aminoimidazole‐4‐carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation. AICA and adenosine are markers
We read with interest the article by Kremer (1) reviewing the mechanisms of action of methotrexate (MTX) and potential mechanisms of MTX resistance. One facet that Kremer highlighted is the role of drug efflux transporters in mediating resistance to MTX. Although he highlights the role of multidrug