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Folic acid analogs. Modifications in the benzene-ring region. 5. 2′,6′-diazafolic acid

✍ Scribed by Eugene C. Roberts; Y. Fulmer Shealy

Book ID: 112123223
Publisher: Journal of Heterocyclic Chemistry
Year: 1974
Tongue: English
Weight: 286 KB
Volume: 11
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570110418

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## Abstract magnified image The immunomodulatory macrolide ascomycin (**1a**) inhibits T‐cell activation __via__ binding to macrophilin‐12 and inhibition of the phosphatase calcineurin. Its structural analogs pimecrolimus and tacrolimus have recently become available as the first novel topical tre