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Folding Transition-State and Denatured-State Ensembles of FSD-1 from Folding and Unfolding Simulations

✍ Scribed by Lei, Hongxing; Dastidar, Shubhra Ghosh; Duan, Yong

Book ID
115522492
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
413 KB
Volume
110
Category
Article
ISSN
0022-3654

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It has been shown that human stefin B exhibits molten globule intermediates when denatured by acid or GuHCl. In the presence of TFE, it transforms into a highly helical state. In our first study on its folding mechanism (Z Λ‡erovnik et al., Proteins 32:296-303), the kinetics measured by circular dich