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Folding thermodynamics and kinetics of the leucine-rich repeat domain of the virulence factor Internalin B

✍ Scribed by Naomi Courtemanche; Doug Barrick

Book ID
111753101
Publisher
Cold Spring Harbor Laboratory Press
Year
2008
Tongue
English
Weight
452 KB
Volume
17
Category
Article
ISSN
0961-8368

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## Abstract Mutations in the __leucine‐rich repeat kinase 2__ (__LRRK2__) gene are the leading cause of genetically inherited Parkinson's disease (PD). Although this multidomain protein has been shown to have both GTPase and kinase activities through the Roc and MAPKKK domains, respectively, the pr