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Folding of a designed simple ankyrin repeat protein

✍ Scribed by V. Sathya Devi; H. Kaspar Binz; Michael T. Stumpp; Andreas Plückthun; Hans Rudolf Bosshard; Ilian Jelesarov

Book ID
119824581
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
126 KB
Volume
13
Category
Article
ISSN
0961-8368

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✍ Moritz Winger; Wilfred F. van Gunsteren 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 690 KB

## Abstract In earlier work, two highly homologous (87% sequence identity) ankyrin repeat (AR) proteins, E3\_5 and E3\_19, were studied using molecular‐dynamics (MD) simulation. Their stabilities were compared, and it was found that the C‐terminal capping unit is unstable in the protein E3\_19, in