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Folding energetics of a multidomain protein, flagellin

✍ Scribed by Shinya Honda; Hatsuho Uedaira; Ferenc Vonderviszt; Shun-ichi Kidokoro; Keiichi Namba


Book ID
115629700
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
400 KB
Volume
293
Category
Article
ISSN
0022-2836

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The available experimental data on the kinetics of unfolding and refolding of small proteins are reviewed. Excluding slow transitions in the unfolded protein due to cis- trans isomerization of peptide bonds, the rate-limiting transition state in both unfolding and refolding is concluded to be a high