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Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors

โœ Scribed by Yingjuan Lu, Philip S. Low

Book ID
105966528
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
260 KB
Volume
51
Category
Article
ISSN
0340-7004

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We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate-hapten conjugates. In antihapten-immunized hosts, this targeted localization of foreign haptens to tumor cells led to rapid accumulation of autologous a