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Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential

โœ Scribed by Yingjuan Lu; Emanuela Sega; Christopher P. Leamon; Philip S. Low

Book ID
113417817
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
605 KB
Volume
56
Category
Article
ISSN
0169-409X

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โœ Yingjuan Lu; Emanuela Sega; Philip S. Low ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 202 KB ๐Ÿ‘ 1 views

We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate-hapten conjugates. In antihapten-immunized hosts, this targeted localization of foreign haptens to tumor cells led to rapid accumulation of autologous a