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Folate-Liposome-Mediated Antisense Oligodeoxynucleotide Targeting to Cancer Cells: Evaluation in Vitro and in Vivo

✍ Scribed by Leamon, Christopher P.; Cooper, Scott R.; Hardee, Gregory E.


Book ID
120232392
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
317 KB
Volume
14
Category
Article
ISSN
1043-1802

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## Abstract In the current study, we evaluated the efficiency of folate‐polyamidoamine dendrimers conjugates (FA‐PAMAM) for the __in situ__ delivery of therapeutic antisense oligonucleotides (ASODN) that could inhibit the growth of C6 glioma cells. Folic acid was coupled to the surface amino groups