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Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis

✍ Scribed by Tiancheng Lu; Jing Sun; Xuexi Chen; Peibiao Zhang; Xiabin Jing

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
888 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

A folate‐conjugated copolymer PEG‐PLA‐PLL/folate was synthesized and mixed with pure PEG‐PLA‐PLL and a fluorescent model drug mFITC to prepare folate‐conjugated micelles. The distribution of micelles was studied on cancer‐cell‐bearing mice via frozen slicing. The results show that mFITC is successfully encapsulated into folate(+) and folate(−)micelles; PEG‐PLA‐PLL micelles the latter can be internalized by both HeLa and CHO cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by HeLa cells than by CHO cells. The folate(−)micelles showed retention in both organs and tumors. The folate(+)micelles are a promising active targeting drug delivery system for FR over‐expressing cells and they accumulate in tumor beds.

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