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Folate antagonists. 8. Synthesis and antimalarial effects of 2,4-Diamino-6-[(aryl and pyridyl)methyl]-6,7-dihydro-7-methyl-5H-pyrrolo[3,4-d] pyrimidines

✍ Scribed by Edward F. Elslager; Ann Curry; Leslie M. Werbel

Book ID: 112122784
Publisher: Journal of Heterocyclic Chemistry
Year: 1972
Tongue: English
Weight: 353 KB
Volume: 9
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570090529

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## Abstract __N__‐(2‐Amino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**9**) and __N__‐(2,4‐diamino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**6**) were synthesized from __N__‐(4‐oxocyclohexyl)acetamide (**5**) as novel peptidomimetic building blocks. With similar purpose, __N__‐(6‐oxo‐5,6,7,