✦ LIBER ✦

Folate antagonists. 14. Synthesis of pyrazino[2,3-f]quinazoline-8,10-diamines and related heterocycles as potential antimalarial agents (1,2)

✍ Scribed by Judith Johnson; Edward F. Elslager; Leslie M. Werbel

Book ID: 112125764
Publisher: Journal of Heterocyclic Chemistry
Year: 1979
Tongue: English
Weight: 207 KB
Volume: 16
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570160604

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Amidines. 5. Synthesis of pyrrolo[2,3,-b

Amidines. 5. Synthesis of pyrrolo[2,3,-b]isoquinoline imidazo[1,2-b]isoquinoline, pyrrolo[2,1-b]quinazoline, and 1,3-thiazino[2,3-b]quinazoline derivatives and related heterocycles as potential antihypertensive agents

✍ Jen, Timothy; Dienel, Barbara; Dowalo, Frederic; Van Hoeven, Helene; Bender, Pau 📂 Article 📅 1973 🏛 American Chemical Society 🌐 English ⚖ 620 KB

Synthesis of 1,3-diamino-7,8,9,10-tetrah

Synthesis of 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]-quinazolines. Inhibitors of Candida albicans dihydrofolate reductase as potential antifungal agents

✍ Joseph H. Chan; David P. Baccanari; Robert L. Tansik; Christine M. Boytos; Sharo 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 637 KB

## Abstract A series of novel 1,3‐diamino‐7,8,9,10‐tetrahydropyrido[3,2‐__f__]quinazolines were synthesized starting from 6‐amino‐5‐cyanoquinoline (4). These compounds inhibited __Candida albicans__ dihydrofolate reductase with K~i~ values of ≤0.60 a__M.__ One analogue exhibited moderate __in vivo_

ChemInform Abstract: Synthesis of 1,3-Di

ChemInform Abstract: Synthesis of 1,3-Diamino-7,8,9,10-tetrahydropyrido(3,2-f)quinazolines. Inhibitors of Candida albicans Dihydrofolate Reductase as Potential Antifungal Agents.

✍ J. H. CHAN; J. S. HONG; L. F. KUYPER; M. L. JONES; D. P. BACCANARI; R. L. TANSIK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Pyrimido[4,5-c]isoquinolines. 2. Synthes

Pyrimido[4,5-c]isoquinolines. 2. Synthesis and biological evaluation of some 6-alkyl-, 6-aralkyl-, and 6-aryl-1,3-diamino-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolines as potential folate antagonists

✍ Rosowsky, Andre; Papathanasopoulos, Nickolas 📂 Article 📅 1974 🏛 American Chemical Society 🌐 English ⚖ 606 KB