## Abstract An increased risk of facial clefts has been observed among mothers with lower intake of folic acid or vitamin A around conception. We hypothesized that the risk of clefts may be further moderated by genes involved in metabolizing folate or vitamin A. We included 425 case‐parent triads i
Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
✍ Scribed by Abee L. Boyles; Allen J. Wilcox; Jack A. Taylor; Klaus Meyer; Åse Fredriksen; Per Magne Ueland; Christian A. Drevon; Stein Emil Vollset; Rolv Terje Lie
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 347 KB
- Volume
- 146A
- Category
- Article
- ISSN
- 1552-4825
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📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND Maternal folate intake and related biomarkers have been inconsistently associated with a risk of oral clefts. ## METHODS Maternal concentrations of plasma folate (PF) and erythrocyte folate (EF), plasma pyridoxal‐5′‐phosphate (PLP; active vitamin B~6~) and total plasma
BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD