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Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts

✍ Scribed by Abee L. Boyles; Allen J. Wilcox; Jack A. Taylor; Klaus Meyer; Åse Fredriksen; Per Magne Ueland; Christian A. Drevon; Stein Emil Vollset; Rolv Terje Lie


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
347 KB
Volume
146A
Category
Article
ISSN
1552-4825

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BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD