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Focal myopathy associated with chronic intramuscular injection of piritramide

✍ Scribed by Peter Y.K. Van den Bergh; Lamia Guettat; Bruno C. vande Berg; Jean-Jacques Martin

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 139 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199712)20:12<1598::aid-mus18>3.0.co;2-x

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✦ Synopsis

We report a patient in whom chronic intramuscular piritramide led to a focal fibrotic myopathy. Since piritramide myotoxicity has never been reported, we have studied its effect on rat skeletal muscle. Chronic intramuscular piritramide led to fibrous connective tissue replacement of rat skeletal muscle, similar to that found in the patient's muscle. Although the pathogenetic mechanism of piritramide myopathy is unclear, we caution against prolonged intramuscular use of piritramide to prevent this potentially debilitating adverse effect.

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