Focal glomerulonephritis in the course of hydralazine-induced lupus syndrome

A short course of BG9588 (anti–CD40 liga

A short course of BG9588 (anti–CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

✍ Dimitrios T. Boumpas; Richard Furie; Susan Manzi; Gabor G. Illei; Daniel J. Wall 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## Abstract ## Objective CD40–CD40 ligand (CD40L) interactions play a significant role in the production of autoantibodies and tissue injury in lupus nephritis. We performed an open‐label, multiple‐dose study to evaluate the safety, efficacy, and pharmacokinetics of BG9588, a humanized anti‐CD40L