Focal Controlled Drug Delivery

✍ Scribed by Abraham J. Domb, Wahid Khan (eds.)

• Publisher: Springer US
• Year: 2014
• Tongue: English
• Leaves: 700
• Series: Advances in Delivery Science and Technology
• Edition: 1
• Category: Library

✦ Synopsis

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

✦ Table of Contents

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Biodegradable Polymers for Focal Delivery Systems....Pages 3-32
Implantable Medical Devices....Pages 33-59
Systemic Targeting Systems-EPR Effect, Ligand Targeting Systems....Pages 61-91
Liposomal Formulations for Focal and Targeted Drug Delivery in Cancer and Other Diseases....Pages 93-116
Polymer–Drug Conjugate in Focal Drug Delivery....Pages 117-147
Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs....Pages 149-166
Front Matter....Pages 167-167
Treatment of Brain Tumors....Pages 169-194
Intranasal Delivery of Neuropeptide-Loaded Nanoparticles and Their Application to Nervous System Therapeutics....Pages 195-213
Focal Drug Delivery in Inner Ear Therapy....Pages 215-224
Nanotechnology-Based Ophthalmic Drug Delivery System....Pages 225-241
Site-Specific Ocular Nucleic Acid Delivery....Pages 243-262
Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin....Pages 263-284
Local Drug Delivery to the Oral Cavity....Pages 285-304
Focal Drug Delivery for Management of Oral Infections....Pages 305-327
Segmental-Dependent Drug Absorption and Delivery: The Stomach....Pages 329-341
Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract....Pages 343-357
Nanotechnology Applications in Local Arterial Drug Delivery....Pages 359-385
Drug-Eluting Stents....Pages 387-403
Drug-Eluting Vascular Grafts....Pages 405-427
Delivery Systems for Lymphatic Targeting....Pages 429-458
Front Matter....Pages 167-167
Antibiotics Delivery for Treating Bone Infections....Pages 459-472
Spatiotemporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair....Pages 473-509
Polymer-Based Drug Delivery Systems for Solid Tumor Treatment....Pages 511-534
Topical Nanointerventions for Therapeutic and Cosmeceutical Applications....Pages 535-560
Focal Drug Delivery to the Nail....Pages 561-584
Drug Delivery to Wounds, Burns, and Diabetes-Related Ulcers....Pages 585-605
Vaginal Drug Delivery....Pages 607-651
Prolonged Duration Local Anesthesia....Pages 653-677
Back Matter....Pages 679-700

✦ Subjects

Pharmaceutical Sciences/Technology