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Focal adhesion kinase mediates TGF-β1-induced renal tubular epithelial-to-mesenchymal transition in vitro

✍ Scribed by Bingqing Deng; Xiao Yang; Jianshe Liu; Fangfang He; Zhonghua Zhu; Chun Zhang

Publisher: Springer
Year: 2010
Tongue: English
Weight: 644 KB
Volume: 340
Category: Article
ISSN: 0300-8177
DOI: 10.1007/s11010-010-0396-7

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## Abstract Idiopathic pulmonary fibrosis is characterized by myofibroblast accumulation, extracellular matrix (ECM) remodeling, and excessive collagen deposition. ECM‐producing myofibroblasts may originate from epithelial cells through epithelial to mesenchymal transition (EMT). TGF‐β1 is an induc