Focal adhesion kinase in keratinocyte adhesion
โ Scribed by Lawrence T Kim; Jianhua Wu; Richard H Turnage
- Book ID
- 114353859
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 267 KB
- Volume
- 191
- Category
- Article
- ISSN
- 1072-7515
No coin nor oath required. For personal study only.
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Focal adhesion kinase (pp125FAK) has well-established functions in the attachment and growth of cells in culture and has been implicated as a marker of malignant progression in human tumors. To evaluate its role in the metastatic conversion of mouse skin tumors, pp125FAK activity and protein express
## Abstract During the healing process of skin wounds, human keratinocytes migrate across a provisional matrix of the wound bed. The mechanisms by which keratinocytes migrate on connective tissue are not known. In this study, we examined the role of focal adhesion kinase (FAK), an 125 kDa protein t