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Fmoc/solid-phase synthesis of Tyr(P)-containing peptides through t-butyl phosphate protection

✍ Scribed by PERICH, JOHN W. ;REYNOLDS, ERIC C.

Book ID: 115099205
Publisher: Wiley (Blackwell Publishing)
Year: 2009
Tongue: English
Weight: 285 KB
Volume: 37
Category: Article
ISSN: 0367-8377
DOI: 10.1111/j.1399-3011.1991.tb00777.x

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A novel method for the efficient synthesis of Tyr(P)-containing peptides is described by the 'phosphite-triester' phosphorylation of the tyrosine residue after its incorporation into the peptide chain. In this approach, the peptide resin is assembled by Fmoc solid-phase peptide synthesis (PyBOP ® co