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Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells

✍ Scribed by Miho Nakano; Kenichi Osada; Atsushi Misonoo; Keisuke Fujiwara; Miho Takahashi; Yuriko Ogawa; Toshiaki Haga; Shigeto Kanai; Daisuke Tanaka; Yasuo Sasuga; Takuyoh Yanagida; Mikio Asakura; Noboru Yamaguchi

Book ID: 116719723
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 579 KB
Volume: 86
Category: Article
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2009.11.017

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## Abstract Reactive astrogliosis is a prominent neuropathologic feature of manganism, a neurodegenerative disorder caused by excessive accumulation of manganese (Mn) in the basal ganglia. Activation of astrocytes has been linked to neuronal injury in manganism resulting from overproduction of infl