๐”– Bobbio Scriptorium
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Flushing in rosacea: A possible mechanism

โœ Scribed by Marcella Guarrera; Aurora Parodi; Carla Cipriani; Carla Divano; Alfredo Rebora

Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
291 KB
Volume
272
Category
Article
ISSN
0340-3696

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โœฆ Synopsis

Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.

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