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Fluoxetine treatment of acral lick dermatitis in dogs: A placebo-controlled randomized double blind trial

✍ Scribed by Dora Wynchank; Michael Berk

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
46 KB
Volume
8
Category
Article
ISSN
1091-4269

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✦ Synopsis

The aim of the study was to assess the efficacy and tolerability of fluoxetine treatment of acral lick dermatitis (ALD) in dogs and to investigate ALD as an animal model of obsessive-compulsive disorder (OCD). Sixty-three dogs with

ALD were treated with fluoxetine 20 mg daily, or placebo, for 6 weeks. In the fluoxetine group, owners rated both appearance of the lesion (t = 10.2, df = 29, P < 0.0001) and licking behavior (t = 10.2, df = 29, P < 0.0001) as significantly improved by the end of the trial. Veterinarian-rated pre-and posttreatment photographs showed statistically significant improvement in the fluoxetine group (mean = 2.55). There were no significant changes in the placebo group as rated by owners and veterinarians. These results demonstrate the efficacy of fluoxetine in the treatment of ALD and lend further support to ALD as an animal model of OCD. Depression and Anxiety 8:21-23, 1998.

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