Fluorous-Silica-Supported Perfluoro-Tagged Palladium Complexes Catalyze Suzuki Couplings in Water

✍ Scribed by Carl Christoph Tzschucke; Willi Bannwarth

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 158 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490260

✦ Synopsis

Abstract

Different Pd‐complexes (see 2a–d and 3) with and without perfluoroalkyl tags were deposited on fluorous reversed‐phase silica 1 and unmodified silica gel. These supported complexes were successfully used as precatalysts for the Suzuki reaction in H~2~O. H~2~O‐Soluble aryl bromides were easily converted to the corresponding biphenyls. Although none of the complexes is H~2~O‐soluble, the active catalyst is most likely homogeneously dissolved. Nevertheless, the Pd‐leaching into the product was low.