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Fluorous “racemic” mixture synthesis: Polysaccharide-based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds

✍ Scribed by Takayuki Tonoi; Wei Zhang; Dennis P. Curran; Koichi Mikami

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 485 KB
Volume: 20
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.20487

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✦ Synopsis

Abstract

The proof of concept experiments of fluorous “racemic” mixture synthesis (FRMS) is shown using polysaccharide‐based chiral stationary phases. The mixture of racemic O‐benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide‐based chiral HPLC columns (DAICEL CHIRALCEL® and CHIRALPAK® series). Chirality, 2008. © 2008 Wiley‐Liss, Inc.

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Fluorous “Racemic” Mixture Synthesis: Simultaneous Strategy for Demixing and Enantioseparation of Racemic Fluorous-Tagged Products

✍ Takayuki Tonoi; Koichi Mikami 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 1 views

## Abstract Reported herein is the concept of fluorous “racemic” mixture synthesis (FRMS), which is applied to two types of proof‐of‐concept experiments. Mixtures of racemic __O__‐benzoylmandelate derivatives and prochiral crotonamide derivatives, respectively, bearing different lengths of fluorous