Fluorouracil (F), adriamycin (A), and cisplatin (P) (FAP): Combination chemotherapy of advanced esophageal carcinoma

✍ Scribed by Dr. Christian Gisselbrecht; Fabien Calvo; Laurent Mignot; Eric Pujade; Michel Bouvry; Odile Danne; Dominique Belpomme; Michel Marty

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 333 KB
• Volume: 52
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19830915)52:6<974::aid-cncr2820520607>3.0.co;2-#

✦ Synopsis

Twenty-one patients with advanced epidermoid carcinoma of the esophagus were treated with a combination of 5-fluorouracil (F) 600 mg/m2 day 1 and day 8; Adriamycin (A) 30 mg/m2 day 1; and cisplatin (P) 75 mg/m2 day 1 (FAP) with hydration and mannitol-induced diuresis. Each course was repeated every 4 weeks. All 21 patients are evaluable for response: 7 patients had an objective response (33%). Two of these responses were complete remissions according to negative endoscopic and pathologic results; five patients had a partial response; all 7 responding patients had metastasis prior to treatment. Median survival of the 21 patients was 8 months. Median survival of 9 months for responders is superior to 4.5 months for nonresponders. No severe myelosuppression or nephrotoxicity was observed. This FAP regimen is useful in the treatment of advanced esophageal tumors.