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Fluoroquinolone Resistance Linked to BothgyrAandparCMutations in the Quinolone Resistance–Determining Region ofShigella dysenteriaeType 1

✍ Scribed by Kaisar A. Talukder; Bijay K. Khajanchi; Mohammad A. Islam; Zhahirul Islam; Dilip K. Dutta; Mustafizur Rahman; Haruo Watanabe; Gopinath B. Nair; David A. Sack

Publisher
Springer
Year
2006
Tongue
English
Weight
76 KB
Volume
52
Category
Article
ISSN
0343-8651

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Mechanism of Binding of Fluoroquinolones to the Quinolone Resistance-Determining Region of DNA Gyrase: Towards an Understanding of the Molecular Basis of Quinolone Resistance
✍ Sergio Madurga; Javier Sánchez-Céspedes; Ignasi Belda; Jordi Vila; Ernest Giralt 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 675 KB

## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone–gyrase interaction remain unclea