Fluoroolefin dipeptide isosteres -II. : Enantioselectlve synthesis of both antipodes of the phe-gly dlpeptide mimic

Fluoroolefin dipeptide isosteres — I.: T

Fluoroolefin dipeptide isosteres — I.: The synthesis of Glyψ(CFCH)Gly and racemic Pheψy(CFCH)Gly

✍ Thomas Allmendinger; Pascal Furet; Ernst Hungerbühler 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 255 KB

The syntheses of Gly-Gly and racemic Phe-Gly fluoroolefin dipeptide isosteres are described, the firs-f examples of a new class of peptkle anabgues. The use of non-hydrolyzable amide isosteres is an established approach 12 to overcoming one of the major drawbacks in the use of peptides as therapeut