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Fluorometric HPLC Determination of -Aminolevulinic Acid (ALA) in the Plasma and Urine of Lead Workers: Biological Indicators of Lead Exposure

✍ Scribed by Oishi, H.; Nomiyama, H.; Nomiyama, K.; Tomokuni, K.

Book ID
126509812
Publisher
Preston Publications
Year
1996
Tongue
English
Weight
941 KB
Volume
20
Category
Article
ISSN
0146-4760

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The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr