Fluorometric assay of verapamil in biological fluids and tissues

✍ Scribed by R. G. McAllister; S. M. Howell

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 208 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650330

✦ Synopsis

Verapamil concentrations in blood, urinee, or tissue homogenates may be measured fluorometrically in the 0.1-10-mug/ml range after extraction into heptane and back-extraction into acid; recovery rates are above 87%. The drug apparently is eliminated rapidly in guinea pigs, with a plasma half-life of 45 min.