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Fluorometric Assay for the Determination of DNA–DNA Cross-Links Utilizing Hoechst 33258 at Neutral pH Values

✍ Scribed by P.G. Penketh; K. Shyam; A.C. Sartorelli


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
82 KB
Volume
252
Category
Article
ISSN
0003-2697

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✦ Synopsis


210

nization. This method may prove useful for other tis-rates of three competing conformational reactions that occur when thermally denatured, complementary ccl sues as well.

and non-ccl ss DNAs are rapidly cooled. When thermally denatured non-ccl DNA is rapidly cooled, the REFERENCES strands undergo a rapid intramolecular mispairing re-1. Macdonald, G. J., Demers, L. M., and Greep, R. O. (1973) Fertil. action before any significant proportion of the mole-Steril. 24, 98-103.

cules begins to anneal. Annealing involves a slow asso-