Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition: Identification of ( S ) -N -[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition

✍ Scribed by Wu, Yong-Jin; Davis, Carl D.; Dworetzky, Steven; Fitzpatrick, William C.; Harden, David; He, Huan; Knox, Ronald J.; Newton, Amy E.; Philip, Thomas; Polson, Craig; Sivarao, Digavalli V.; Sun, Li-Qiang; Tertyshnikova, Svetlana; Weaver, David; Yeola, Suresh; Zoeckler, Mary; Sinz, Michael W.

• Book ID: 124097391
• Publisher: American Chemical Society
• Year: 2003
• Tongue: English
• Weight: 82 KB
• Volume: 46
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm034111v