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Fluorine-containing amino acids and their derivatives. 4. Synthesis and antibacterial activity of threo and erythro 1-fluorodehydroxylated chloramphenicol analogs

✍ Scribed by Tsushima, Tadahiko; Kawada, Kenji; Tsuji, Teruji; Tawara, Katsuya


Book ID
126240644
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
577 KB
Volume
28
Category
Article
ISSN
0022-2623

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## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded