Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine

✍ Scribed by Andrew Joseph; Clark Davenport; Lester Kwock; C. Tyler Burt; Robert E. London

• Book ID: 102527577
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 426 KB
• Volume: 4
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910040206

✦ Synopsis

Copenhagen rats with implanted metastatic prostate carcinomas have been treated with the drug alpha-difluoromethylornithine (DFMO), an inhibitor of the enzyme ornithine decarboxylase. In vivo and in vitro 19F NMR observations were then carried out on a variety of organs and tissues. The distribution of the drug strongly favored tumor over surrounding muscle. DFMO, which gives a spectrum similar to that of the pH indicator difluoromethylalanine, has potential for determination of in vivo pH. However, in contrast to the alanine analog, DFMO exhibits a considerably smaller shift dependence in response to pH changes.