✦ LIBER ✦
Fluorination reactions with HF/THF medium solvolysis of N-tosyl-O-phenylhydroxylamine
✍ Scribed by William R. Dolbier Jr.; Lech Celewicz; Keiichi Ohnishi
- Book ID
- 104232988
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 129 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Solvolysis of N-tosyl-0-phenylhydroxylamine in HFm leads to regiospecific formation of p-fluorophenol via umpolung strategy which induces nucleophilic aromatic fluorine/hydrogen substitution.