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Fluorination of nitrogen-containing aromatics with xenon difluoride

โœ Scribed by S.P. Anand; Robert Filler

Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
295 KB
Volume
7
Category
Article
ISSN
0022-1139

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โœฆ Synopsis

Pyridine reacts with xenon difluoride to give a mixture of 2-fluoropyridine, 3-fluoropyridine, and 2,6_difluoropyridine, while 8-hydroxyquinoline is converted to 5-fluoro-8-quinolinol. Aniline and benzylamine react vigorously with XeF, to yield mixtures of monofluoro isomers derived from the parent amines.

๐Ÿ“œ SIMILAR VOLUMES

Fluorination of pyrrolic compounds with
Fluorination of pyrrolic compounds with xenon difluoride
โœ Jianji Wang; A.Ian Scott ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 308 KB

Direct fluorination of the pymole ring with electron-withdrawing gtmym, such as, -CHO, -COR, -COOR, -CON&, using xctm difluoride under mild conditions leads to the comsponding flwtopymAcs in 2544% yields. It was found that fluorination takes place only at the u-position of the pyrrole even when the